ARA-290 (Cibinetide) is a synthetic 11-amino acid peptide modeled on the non-hematopoietic, tissue-protective helix B domain of erythropoietin (EPO). It is engineered to selectively bind the innate repair receptor (IRR)—a heteroreceptor complex composed of the erythropoietin receptor and the CD131 common beta chain—without activating the classical erythropoietic homodimeric EPO receptor. It is supplied strictly for in vitro IRR-mediated anti-inflammatory signaling kinetics, NF-κB transcription inhibition assays, macrophage phenotype switching studies, and laboratory small nerve fiber survival and cellular protection models. Supplied as a stable lyophilized powder suitable for analytical reconstitution.

Technical Specifications

• Chemical Name / Synonym: ARA-290 / Cibinetide / Helix B Surface Peptide (HBSP) / Pyroglu-Glu-Gln-Leu-Glu-Arg-Ala-Leu-Asn-Ser-Ser

• Molecular Formula: C51H84N16O21

• Molecular Weight: 1257.32 g/mol

• Physical Form: Lyophilized solid / cake

• Purity Grade: ≥ 98.0% (analytical verification via HPLC-MS)

• Storage Conditions: Store sealed at -20°C in a dry environment protected from light. Keep desiccated until experimental reconstitution.

Analytical Quality & Testing Every production batch undergoes analytical screening via HPLC and Mass Spectrometry to confirm chemical identity, sequence fidelity, and purity standards. Batch-specific Certificates of Analysis (CoA) and analytical testing records are maintained on file and available to qualified laboratories upon request.

LABORATORY RESEARCH USE ONLY This biochemical reagent is manufactured and distributed strictly for in vitro laboratory experimentation, diagnostic assay development, and analytical testing. It is not a drug, dietary supplement, therapeutic agent, cosmetic, or food product. Not for human, animal, or clinical administration, consumption, injection, or veterinary application. Must be handled exclusively by qualified personnel adhering to standard chemical laboratory safety protocols.