Semax is a synthetic regulatory peptide engineered by extending the adrenocorticotropic hormone fragment ACTH(4-10) with a Pro-Gly-Pro (PGP) tripeptide at the C-terminus (Met-Glu-His-Phe-Pro-Gly-Pro). This C-terminal modification confers significant resistance to carboxypeptidases and endopeptidases while stripping hormonal corticotropic activity. It is supplied strictly for in vitro brain-derived neurotrophic factor (BDNF) and TrkB receptor signaling kinetics, dopaminergic and serotonergic neurotransmitter modulation assays, gene expression profiling of neurotrophic factors, and laboratory neuroprotective signaling models in cell cultures. Supplied as a stable lyophilized powder suitable for analytical reconstitution.

Technical Specifications

• Chemical Name / Synonym: Semax / Heptapeptide Semax / H-Met-Glu-His-Phe-Pro-Gly-Pro-OH / ACTH(4-7)-Pro-Gly-Pro

• Molecular Formula: C37H51N9O10S

• Molecular Weight: 813.92 g/mol

• Physical Form: Lyophilized solid / cake

• Purity Grade: ≥ 98.0% (analytical verification via HPLC-MS)

• Storage Conditions: Store sealed at -20°C in a dry environment protected from light. Keep desiccated until experimental reconstitution.

Analytical Quality & Testing Every production batch undergoes analytical screening via HPLC and Mass Spectrometry to confirm chemical identity, sequence integrity, and purity standards. Batch-specific Certificates of Analysis (CoA) and analytical testing records are maintained on file and available to qualified laboratories upon request.

LABORATORY RESEARCH USE ONLY This biochemical reagent is manufactured and distributed strictly for in vitro laboratory experimentation, diagnostic assay development, and analytical testing. It is not a drug, dietary supplement, therapeutic agent, cosmetic, or food product. Not for human, animal, or clinical administration, consumption, injection, or veterinary application. Must be handled exclusively by qualified personnel adhering to standard chemical laboratory safety protocols.